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#2 GIMP
The GNU Image Manipulation Program offers a full suite of layer types, masks, blending modes, and a powerful GEGL engine for high‑quality compositing.
#3 Krita
A professional digital painting application with unlimited layers, vector layers, group layers, and advanced blending options.
#4 Pixelorama
A lightweight, pixel‑art focused editor that supports multiple layers, frame‑by‑frame animation, and a variety of blend modes.
#5 MyPaint
Optimized for drawing tablets, MyPaint includes a flexible layer system with opacity, blending, and layer groups.
#6 Pinta
A simple yet capable editor inspired by Paint.NET, offering basic layer support, opacity control, and blend modes.
#7 Seashore
Mac‑only raster editor built on Cocoa, featuring layers, gradients, and a variety of blend modes.
#8 PhotoFlare
A fork of PhotoFiltre, PhotoFlare adds true layer handling, masks, and a range of adjustment filters.
#9 Fotoxx
A photo editing suite that includes a layer stack, masks, and non‑destructive adjustments.
#10 Luminance HDR
Specialized HDR editor with layer‑based tone‑mapping, exposure blending, and mask support.
#11 Darktable
A RAW workflow application offering a virtual layer stack via modules, masks, and blend modes for non‑destructive editing.
#12 RawTherapee
Advanced RAW processor with a powerful non‑destructive editing pipeline that mimics layer‑based adjustments.
#13 Pixelitor
Java‑based image editor with unlimited layers, layer groups, masks, and a rich set of blend modes.
#14 Inkscape
Vector graphics editor that treats each object as a layer; supports grouping, clipping, and blend modes for complex compositions.
#15 Natron
Node‑based compositing software offering a full layer/track system, keying, and extensive OpenFX plugins.
While known for 3D, Blender’s compositor provides a node‑based layer system, masks, and advanced blending for 2D work.
#17 Synfig Studio
2D animation suite with a powerful layer hierarchy, vector layers, and bitmap layers, all supporting blend modes.
#18 OpenToonz
Open‑source animation production tool featuring raster and vector layers, effects, and sophisticated compositing options.
A unified version of Krita optimized for both desktop and tablet, retaining full layer capabilities across devices.
#20 GNU Paint
Simple drawing program that now includes basic layer support and opacity controls.